Optimization of Pharmaceutical Product Formulation by Factorial Designs: Case Studies

Pharmaceutical Engineering: Optimization of a Pharmaceutical Formulation

The effects of magnesium stearate (MgSt) and shear stress on flow properties and hydrophobicity are not well known. Blends with different concentrations of magnesium stearate and varying amounts of shear were tested using three different procedures: the FT4 Rheometer test, a tap density analyzer, and the Washburn method, to better understand the relation of lubricant concentration, amount of sh...

designing around patents in the pharmaceutical product development, case studies

Pharmaceutical product design using combinatorial optimization

A two-step computational method for designing new molecules in medicinal chemistry is described. In the first step, topological indices are used to develop structure-based correlations for properties of interest. Zeroth and first order connectivity indices are employed to develop linear correlations for three physical properties of interest in pharmaceutical chemistry: octanol–water partition c...

Model-Robust Factorial Designs

Multistratum Fractional Factorial Designs

Recent work on multistratum fractional factorial designs is set in a general and unified framework, and a criterion for selecting multistratum fractional factorial designs that takes stratum variances into account is proposed. Application of the general theory is illustrated on designs of experiments with multiple processing stages, including split-lot designs, blocked strip-plot designs, and p...